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KMID : 0861020110260010111
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Korea Journal of Herbology
2011 Volume.26 No. 1 p.111 ~ p.117
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Anti-oxidation and Anti-aging Effect of Mixed Extract from Korean Medicinal Herbs
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Hwang Jae-Gyu
Yun Jong-Kuk
Han Kil-Hwan
Do Eun-Ju
Lee Jin-Sang
Lee Eun-Ju
Kim Jong-Boo
Kim Mi-Ryeo
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Abstract
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Objectives:The present study was designed to investigate effects of mixed extract from korean medicinal herbs (MIX) on oxidation/reduction reaction-related and aging-related enzyme in vitro.
Methods: We performed MTT assay, collagenase inhibition assay, elastase inhibition assay, tyrosinase inhibition assay, DPPH free radical scavenging assay, SOD-like activity and xanthine oxidase inhibition assay.
Results:Recently, many studies have reported that elastin is also involved in inhibiting or repairing wrinkle formation, although collagen is a major factor in the skin wrinkle formation. The MIX showed 97% inhibition of collagenase activity, and 64% inhibition of elastase activity at 1 mg/ml concentration of MIX, next only to positive control, which indicate good efficacy for anti-wrinkle ingredient. Also it’s treatment showed 34% inhibition of tyrosinase activity, to relate whitening effect, at the same dose of MIX. Antioxidant activities were determined by DPPH radical scavenging, xanthine oxidase (XO) inhibiting activity and SOD-like activity. Also these scavenging, XO-inhibiting and SOD-like activities were measured in 91%, 80%, and 63% inhibition, respectively, at a treated dose of 1 mg/ml, compare to control.
Conclusions:: These results suggest that possibility of mixed korean medicinal herbs as a functional ingredient for anti-wrinkle and whitening, anti-oxidation and anti-aging cosmetic formula.
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KEYWORD
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Anti-aging, anti-oxidation, collagenase, elastase, tyrosinase
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